Nitroxynil
Nitroxynil is a parenteral flukicide used against susceptible Fasciola and selected blood-feeding nematodes.
Group
Substituted phenol flukicide
Mechanism of Action
Disrupts parasite energy metabolism through uncoupling of oxidative phosphorylation.
Dose Rates
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Susceptible fluke or Haemonchus infection | 10 mg/kg | SC | Once | Use the labelled 10 mg/kg active dose. The rounded 1.5 mL/50 kg example for 340 mg/mL gives approximately 10.2 mg/kg. |
Sheep
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Susceptible fluke or Haemonchus infection | 10 mg/kg | SC | Once | Use the labelled 10 mg/kg active dose. The rounded 1.5 mL/50 kg example for 340 mg/mL gives approximately 10.2 mg/kg. |
Indications
- Fasciolosis in cattle and sheep
- Label-susceptible Haemonchus infection
Contraindications
- Use only by the formulation-supported route; avoid overdose.
Interactions
- Do not combine anthelmintics without checking the complete product protocol.
Adverse effects
- Injection-site swelling or irritation; yellow staining of skin or fleece.
Toxicity
Excess can cause hyperthermia, rapid breathing and neurologic depression. Cool and support the patient; no specific antidote is established.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Nitrox-A Vet injection 340 mg/mL The ACME Laboratories Ltd. | Injection | 340 mg / mL | SC |
Monitoring and Administration
Weigh accurately and use SC injection. Keep staining solution off skin and clothing.
Assess parasite stage and response; treatment does not cover all gastrointestinal worms.