Rafoxanide
Rafoxanide is used against susceptible mature and selected immature liver-fluke stages in ruminants.
Group
Salicylanilide flukicide
Mechanism of Action
Uncouples oxidative phosphorylation in susceptible parasites.
Dose Rates
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciolosis | 7.5 mg/kg | PO | Once | Livestock treatment-guidance regimen; distinct from the higher Ranide cattle label dose. |
| Fasciolosis – Ranide regimen | 11.25 mg/kg | PO | Once | Ranide product-specific cattle regimen; do not replace the separate 7.5 mg/kg guidance by a midpoint. |
Sheep
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciolosis | 7.5 mg/kg | PO | Once | Ranide 30 mg/mL oral drench regimen. |
Indications
- Susceptible fasciolosis
Contraindications
- Hypersensitivity; avoid dosing errors and use particular care in debilitated animals.
Interactions
- Do not combine flukicides without a verified protocol.
Adverse effects
- Reduced appetite, diarrhoea or neurologic signs can occur with excessive exposure.
Toxicity
Overdose may cause neurologic and visual injury; no specific antidote is established.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Ranide oral drench 30 mg/mL Univet Ltd. Cattle and sheep doses differ; follow the matching regimen. | Oral Liquid | 30 mg / mL | PO |
Monitoring and Administration
Weigh accurately and shake suspensions. Product-specific cattle doses differ; do not merge them into a single arbitrary range.
Assess response and parasite resistance. Withdrawal periods depend on product and jurisdiction.