Bromhexine
Bromhexine is an adjunct for respiratory disease in which tenacious mucus impairs clearance.
Group
Mucolytic
Mechanism of Action
Promotes respiratory fluid secretion and reduces mucus glycoprotein-network viscosity.
Dose Rates
Dogs
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 1 mg/kg | PO | Every 12 h | Up to 5 days; Per-dose amount from total daily 2 mg/kg divided twice daily; not 2 mg/kg per dose. |
Cats
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 1 mg/kg | PO | Every 24 h | Up to 7 days |
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 0.5 mg/kg | PO | Every 24 h | Up to 5 days; Do not use in: Cows producing milk for human consumption |
Pigs
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 0.2–0.5 mg/kg | PO | Every 24 h | Up to 5 days |
Indications
- Respiratory disease with tenacious mucus
Contraindications
- Hypersensitivity; the cited powder excludes cows producing milk for human consumption.
Interactions
- May increase oxytetracycline concentrations in bronchial mucus; clinical benefit of this interaction is uncertain.
Adverse effects
- Adverse reactions are not well characterised in the cited veterinary information; hypersensitivity remains possible.
Toxicity
Specific veterinary overdose information is limited; provide supportive care and assess the underlying respiratory disease.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Bisolvon oral powder 10 mg/g Klocke Pharma-Service GmbH 10 mg bromhexine hydrochloride per g powder; dog dose is divided from the total daily amount. | Powder | 10 mg / g | PO |
Monitoring and Administration
Add powder to feed or drinking water immediately before administration; discard uneaten medicated feed or water after 24 hours.
Bisolvon dog label states 2 mg/kg TOTAL DAILY, divided twice daily; each dose is 1 mg/kg. This is also confirmed by its per-treatment powder table.
Store dry below 25°C; reseal opened sachets and discard unused contents within seven days. Cattle meat withdrawal two days and pig meat zero days for the cited powder.