Progesterone
Progesterone provides luteal hormonal activity and is used in controlled reproductive protocols. Natural progesterone is distinct from altrenogest, norgestomet and medroxyprogesterone.
Group
Progestogen hormone
Mechanism of Action
Activates progesterone receptors, suppressing gonadotropin-dependent ovulation while present; withdrawal permits coordinated return to oestrus.
Indications
- Oestrous-cycle synchronization in cattle
Contraindications
- Do not use a vaginal device in animals with an unsuitable genital tract or outside its labelled reproductive population.
Interactions
- GnRH and prostaglandins may be required at specified times; a device is not a complete timed-AI protocol by itself.
Adverse effects
- Transient vaginal mucus/discharge or irritation; device loss may occur.
Toxicity
Remove a retained or incorrectly used device and reassess clinically; absorbed exposure cannot be calculated from the total device content.
Monitoring and Administration
For Eazi-Breed CIDR cattle insert, use one intravaginal device in the complete selected synchronization protocol; total progesterone content is 1.38 g, not an injected or daily systemic dose.
Use gloves and an appropriate applicator; clean and disinfect equipment between animals. Leave the removal tail accessible and remove at the specified time.
Single-use inserts reduce transmission risk; do not infer reuse or substitute sheep and cattle device sizes.
Oestrous-cycle synchronization: Intravaginal device, not external topical application: one cattle CIDR containing 1.38 g progesterone. A commonly labelled course is seven days, with accompanying hormone timing defined by the selected protocol. No daily mass dose is inferred.