Clorsulon
Clorsulon treats susceptible Fasciola infections. Oral and ivermectin-combination injection regimens target different stages at different doses.
Group
Sulfonamide flukicide
Mechanism of Action
Inhibits fluke glycolytic enzymes, restricting ATP production.
Dose Rates
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciola hepatica infection | 7 mg/kg | PO | Once | Oral regimen; not effective against early immature flukes less than about eight weeks old. |
| Adult fluke with ivermectin-susceptible parasites | 2 mg/kg | SC | Once | Ivomec Plus combination delivers ivermectin 0.2 mg/kg at this clorsulon dose; cattle only. |
Sheep
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciola hepatica infection | 7 mg/kg | PO | Once | Oral regimen; not effective against early immature flukes less than about eight weeks old. |
Llamas
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciola hepatica infection | 7 mg/kg | PO | Once | Oral regimen; not effective against early immature flukes less than about eight weeks old. |
Indications
- Susceptible Fasciola hepatica infection
Contraindications
- Cited products exclude female dairy cattle of breeding age.
- Ivermectin/clorsulon cattle injections are not for dogs and are SC only.
Interactions
- No specific clorsulon interaction established in the supplied monograph; combination ivermectin adds its own risks.
Adverse effects
- Oral adverse effects are uncommon; injection-site swelling may occur with combination products.
Toxicity
A broad oral safety margin is described; manage clinically significant overdose supportively and assess the other active in combinations.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Curatrem oral drench 8.5% | Oral Liquid | 85 mg / mL | PO |
| Ivomec Plus injection 100/10 mg per mL Clorsulon-based calculation only for the matching 2 mg/kg combination regimen; not a substitute for 7 mg/kg oral clorsulon. Do not use the 7 mg/kg oral clorsulon dose with this injectable combination. | Injection | clorsulon 100 mg / mL + ivermectin 10 mg / mL | SC |
Monitoring and Administration
Oral 7 mg/kg has activity against flukes from about eight weeks; the 2 mg/kg injectable combination principally targets adults. It does not treat rumen flukes.
Shake oral suspension and assess efficacy. Product withdrawal: Curatrem cattle meat 8 days; Ivomec Plus meat 49 days, with dairy restrictions.