Propylene Glycol
Propylene glycol is an oral glucogenic treatment for hyperketonaemia in dairy cattle. It is not ethylene glycol.
Group
Glucogenic precursor
Mechanism of Action
Rumen and hepatic metabolism supplies glucogenic substrates and supports glucose availability.
Dose Rates
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Hyperketonaemia | 250–400 g/animal | PO | Every 24 h | Up to 5 days; Oral drench for 3-5 days; monitor response and concurrent disease. |
Indications
- Bovine hyperketonaemia
Contraindications
- Avoid dosing animals unable to swallow safely; excessive dosing can depress rumen function.
- Do not extrapolate cattle drench doses to cats, which are sensitive to propylene-glycol-associated erythrocyte injury.
Adverse effects
- Reduced intake, salivation, incoordination or CNS depression with excess.
Toxicity
Stop excessive dosing and provide supportive care; assess rumen function and neurologic status.
Monitoring and Administration
Drench accurately rather than relying on uncertain voluntary intake. Monitor blood beta-hydroxybutyrate, appetite and concurrent fresh-cow disease.
Do not confuse grams with millilitres; use the verified density or concentration of the actual product before converting a mass dose to volume.