Toltrazuril
Toltrazuril is a coccidiocidal antiprotozoal with activity against several intracellular developmental stages. It is not interchangeable by dose with ponazuril.
Group
Triazinone anticoccidial
Mechanism of Action
Interferes with intracellular parasite development, including mitochondrial and cell-division processes.
Dose Rates
Dogs
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Coccidiosis | 15 mg/kg | PO | Every 24 h | Up to 6 days; Course 3-6 days. |
| Coccidiosis | 10–30 mg/kg | PO | Every 24 h | Up to 3 days; Separate published alternative; shortest course 1-3 days for the 10-30 mg/kg regimen. |
| Coccidiosis | 20 mg/kg | PO | Every 24 h | Up to 3 days; Separate published alternative; shortest course 1-3 days for the 10-30 mg/kg regimen. |
| Puppy coccidiosis control | 10–20 mg/kg | PO | Once | Puppies at 3-4 weeks; treat the exposed group as part of hygiene control. |
Cats
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Coccidiosis | 30 mg/kg | PO | Every 24 h | Up to 3 days; For the 30 mg/kg alternative the course is 2-3 days. |
| Coccidiosis | 20 mg/kg | PO | Every 24 h | Up to 3 days; For the 30 mg/kg alternative the course is 2-3 days. |
| Toxoplasma oocyst shedding | 5–10 mg/kg | PO | Every 24 h | Up to 2 days; Targets the enteroepithelial cycle; not an established systemic toxoplasmosis regimen. |
Sheep
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Coccidiosis | 20 mg/kg | PO | Once |
Birds
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Raptor coccidiosis | 7 mg/kg | PO | Every 24 h | Up to 3 days; Course 2-3 days. |
Bearded dragons
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Coccidial parasitism | 5–15 mg/kg | PO | Every 24 h | Up to 3 days |
Chickens
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Coccidiosis | 7 mg/kg | PO | Every 24 h | Up to 2 days; Administer through drinking water using measured flock weight and water intake. |
Indications
- Coccidiosis
- Suppression of feline Toxoplasma oocyst shedding
Contraindications
- Hypersensitivity to toltrazuril; food-animal milk and egg restrictions are formulation-specific.
Adverse effects
- Gastrointestinal upset; reduced water intake at excessive doses.
Toxicity
Provide supportive treatment; overdosing water medication may reduce intake and cause underhydration.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Toltracure-2.5 oral solution International Health Care Limited Poultry drinking-water solution, not an injection. | Oral Liquid | 25 mg / mL | PO |
| Toltrazuril 2.5% oral solution – Better Pharma Better Pharma Co. Ltd. Poultry drinking-water presentation; registry evidence does not establish current registration renewal. | Oral Liquid | 25 mg / mL | PO |
Monitoring and Administration
Shake suspensions and distinguish individual-animal suspensions from alkaline poultry drinking-water concentrates.
For 2.5% water solution, prepare fresh medicated water daily; overly concentrated dilution can precipitate. Do not assume a poultry concentrate is a suitable oral product for every species.