Cefoperazone
Cefoperazone is a beta-lactam antibacterial used in certain intramammary mastitis products and selected systemic formulations.
Group
Third-generation cephalosporin antibacterial
Mechanism of Action
Binds bacterial penicillin-binding proteins and inhibits cell-wall synthesis.
Dose Rates
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Systemic combination product – unresolved dose basis | Reference only | IM, IV | Every 24 h | Up to 5 days; DOTCEF-S cattle/buffalo information states 10 mg/kg every 24 hours for 3-5 days, but does not state component versus combined-total basis. Numeric calculation is not enabled pending clarification. |
Buffaloes
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Systemic combination product – unresolved dose basis | Reference only | IM, IV | Every 24 h | Up to 5 days; DOTCEF-S cattle/buffalo information states 10 mg/kg every 24 hours for 3-5 days, but does not state component versus combined-total basis. Numeric calculation is not enabled pending clarification. |
Indications
- Mastitis caused by susceptible organisms
Contraindications
- Cephalosporin hypersensitivity; assess cross-sensitivity with penicillins.
Interactions
- Do not mix intramammary preparations or systemic combinations without compatibility data.
Adverse effects
- Hypersensitivity; local irritation; gastrointestinal disturbance with systemic exposure.
Toxicity
Stop treatment for hypersensitivity and provide supportive treatment.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Cefvel Vet 4.5 g vial Morvel Laboratories Pvt. Ltd. Manufacturer states sodium salts 3 g/1.5 g. Component equivalence and final solution concentration are not inferred from diluent volume. No component calculation selected. | Injection | cefoperazone sodium 3000 mg / vial + sulbactam sodium 1500 mg / vial | IM, IV |
Monitoring and Administration
Obtain aseptic milk samples before treatment where feasible. Infuse only the affected quarter with an intramammary product after milking and teat-end disinfection.
Intramammary dosing is per quarter and cannot be represented as TOPICAL, IM or a whole-animal mg/kg regimen.
Susceptible mastitis: Intramammary route, not external topical application: a 250 mg cefoperazone syringe is used per affected quarter. Do not infer retreatment timing from the milking interval.
Systemic cefoperazone/sulbactam product information is not uniform: one catalogue specifies 5-10 mg cefoperazone/kg by IM or IV without a repeat interval; another cattle/buffalo page specifies 10 mg/kg every 24 hours for 3-5 days but does not resolve whether this is cefoperazone or combined total. These must not be merged into an invented component-based schedule.