Triclabendazole
Triclabendazole is a narrow-spectrum flukicide active against susceptible early immature, immature and adult Fasciola.
Group
Benzimidazole flukicide
Mechanism of Action
Its active metabolites disrupt fluke microtubule-related processes and tegumental function.
Dose Rates
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciolosis | 12 mg/kg | PO | Once |
Sheep
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Fasciolosis | 10 mg/kg | PO | Once |
Indications
- Acute, subacute and chronic fasciolosis
Contraindications
- Hypersensitivity; food-animal milk restrictions vary by exact product.
Interactions
- Do not substitute combination products without checking all active ingredients.
Adverse effects
- Adverse reactions are uncommon at recommended doses; hypersensitivity is possible.
Toxicity
Marked overdose may cause reduced appetite, weight loss and altered activity; treat supportively.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Tribex 100 mg/mL oral suspension | Oral Liquid | 100 mg / mL | PO |
| Olgard oral suspension Also contains ivermectin 0.1% w/v; the single-drug regimen does not determine safe combination use. | Oral Liquid | triclabendazole 50 mg / mL + ivermectin 1 mg / mL | PO |
Monitoring and Administration
Shake suspension, weigh animals accurately and investigate suspected resistance rather than repeatedly redosing.
Tribex 100 mg/mL: cattle meat withdrawal 56 days; not for lactating animals producing milk for consumption. Dry-cow use has specific calving restrictions.