Analgin (Metamizole Sodium)
Metamizole, also called dipyrone or analgin, is a prodrug used for analgesia and reduction of fever. Equine antipyretic efficacy is better established than antispasmodic efficacy.
Group
Pyrazolone analgesic and antipyretic
Mechanism of Action
Active metabolites produce central analgesic and antipyretic effects; its actions differ from those of conventional peripheral NSAIDs.
Dose Rates
Horses
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Pyrexia | 30 mg/kg | IV | Every 12 h | Up to 3 days |
Dogs
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Analgesia | 50 mg/kg | IV, IM, SC | Every 12 h | Parenteral small-animal regimen; IM and SC injections can be irritating. Do not apply these routes to an IV-only product. |
Indications
- Fever in horses
- Analgesia in dogs
Contraindications
- Hypersensitivity; avoid when gastrointestinal ulceration or significant renal compromise makes analgesic treatment unsafe.
Interactions
- Avoid concurrent NSAIDs, corticosteroids and other ulcerogenic drugs.
Adverse effects
- Injection irritation; gastrointestinal ulceration or colitis can occur.
- Platelet function may be inhibited; agranulocytosis is a recognised human risk, without an established equine incidence.
Toxicity
Provide supportive treatment for overdose and monitor gastrointestinal bleeding, renal function and blood counts.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Zimeta 500 mg/mL injection Equine antipyretic product; administer by IV injection. | Injection | 500 mg / mL | IV |
Monitoring and Administration
Use the formulation-specific route. The equine 500 mg/mL product is for IV use; IM/SC administration can irritate tissue.
Monitor hydration, gastrointestinal signs, protein loss, bleeding and temperature.