Table of Contents 16 sections Group Mechanism of Action Dose Rates Cattle Sheep Goats Pigs Horses Dogs Cats Indications Contraindications Adverse effects Toxicity Preparations Monitoring and Administration
Ethamsylate (Etamsylate) Etamsylate supports primary haemostasis in capillary bleeding associated with surgery, trauma or obstetric disease.
Systemic haemostatic
Promotes platelet adhesion and capillary resistance without replacing deficient coagulation factors.
Cattle Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Sheep Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Goats Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Pigs Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Horses Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Dogs Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Cats Use / stage Dose Route Schedule Instructions Surgical haemorrhage prevention 5–12.5 mg/kg IV, IM Once Administer at least 30 minutes before surgery. Ongoing haemorrhage 5–12.5 mg/kg IV, IM Every 6 h Up to 4 days; Repeat only while bleeding persists. Treatment may be needed for one day, with a further 2-3 days in some cases.
Surgical haemorrhage prevention Traumatic or obstetric haemorrhage Hypersensitivity to etamsylate or sulfite-containing excipients. Hypersensitivity reactions are possible. No specific antidote is established; treat adverse reactions supportively.
Preparation Form Strength Route Hemosilate 125 mg/mL Injection 125 mg / mL IV, IM
Ligate disrupted large vessels; etamsylate cannot close them.
Give prophylactic treatment at least 30 minutes before surgery. For the 125 mg/mL injection, use a maximum of 20 mL per injection site and separate sites when necessary.
