Table of Contents 20 sections Group Mechanism of Action Dose Rates Dogs Cats Pigs Cattle Ferrets Rabbits Gerbils Hamsters Rats Birds Reptiles Indications Contraindications Adverse effects Toxicity Preparations Monitoring and Administration
Tylosin Tylosin is a macrolide antibacterial.
Macrolide antibacterial
Binds bacterial 50S ribosomes and inhibits protein synthesis.
Dogs Use / stage Dose Route Schedule Instructions Susceptible infection 7–15 mg/kg PO Every 12–24 h Susceptible infection 8–11 mg/kg IM Every 12 h Colitis — Initial 12–20 mg/kg PO Every 8 h Give with food; lengthen interval stepwise only after response. Colitis — Maintenance 12–20 mg/kg PO Every 12 h Give with food; lengthen interval stepwise only after response. Colitis — Maintenance 12–20 mg/kg PO Every 24 h Give with food; lengthen interval stepwise only after response. Inflammatory bowel disease adjunct 10 mg/kg PO Every 8 h Up to 21 days Clostridial colitis 10–40 mg/kg PO Every 12 h Inflammatory bowel disease or antibiotic-responsive diarrhea 20–40 mg/kg PO Every 12 h Small intestinal bacterial overgrowth 10–20 mg/kg PO Every 12 h Up to 42 days Tylosin-responsive diarrhea 25 mg/kg PO Every 24 h Up to 7 days; Study course 7 days; relapse may follow withdrawal.
Cats Use / stage Dose Route Schedule Instructions Susceptible infection 7–15 mg/kg PO Every 12–24 h Susceptible infection 8–11 mg/kg IM Every 12 h Inflammatory bowel disease adjunct 10 mg/kg PO Every 8 h Up to 21 days Clostridial colitis 10–40 mg/kg PO Every 12 h Inflammatory bowel disease or antibiotic-responsive diarrhea 20–40 mg/kg PO Every 12 h Inflammatory bowel disease 40 mg/kg PO Every 12 h
Pigs Use / stage Dose Route Schedule Instructions Arthritis, erysipelas or dysentery 8.8 mg/kg IM Every 12 h Bacterial infection with tylosin base 12.5 mg/kg IM Every 12 h
Cattle Use / stage Dose Route Schedule Instructions Pododermatitis or pneumonia 17.6 mg/kg IM Every 24 h Refractory bacterial pneumonia 44 mg/kg IM Every 24 h 200 mg/mL product, specific resistant-infection report; historical foreign withdrawal is not local authorization. Bacterial infection with tylosin base — Loading 10 mg/kg IM Once Bacterial infection with tylosin base — Maintenance 6 mg/kg IM Every 8 h Calf interval alternative every 8-12 hours.
Ferrets Use / stage Dose Route Schedule Instructions Susceptible infection 10 mg/kg PO Every 12–24 h
Rabbits Use / stage Dose Route Schedule Instructions Susceptible infection 10 mg/kg SC, IM Every 12–24 h Historical rabbit use conflicts with guidance contraindicating oral administration; route remains unresolved.
Gerbils Use / stage Dose Route Schedule Instructions Susceptible infection 10 mg/kg SC Every 24 h
Hamsters Use / stage Dose Route Schedule Instructions Susceptible infection 10 mg/kg SC Every 24 h
Rats Use / stage Dose Route Schedule Instructions Susceptible infection 10 mg/kg SC Every 24 h
Birds Use / stage Dose Route Schedule Instructions Upper respiratory infection 40 mg/kg IM 200 mg/mL preparation; often a combination protocol. Upper respiratory infection or airsacculitis 10–40 mg/kg IM Every 8–12 h Susceptible infection 30 mg/kg IM Every 12 h
Reptiles Use / stage Dose Route Schedule Instructions Susceptible infection 5 mg/kg IM Every 24 h Tortoise chronic respiratory courses are reported for at least 10 days.
Susceptible bovine and swine infection Selected canine colitis Inflammatory bowel disease adjunct Clostridial colitis Inflammatory bowel disease or antibiotic-responsive diarrhea Small intestinal bacterial overgrowth Tylosin-responsive diarrhea Inflammatory bowel disease Bacterial infection with tylosin base Refractory bacterial pneumonia Susceptible infection Upper respiratory infection Upper respiratory infection or airsacculitis Horses Do not administer orally to rabbits or rodents. Avoid IV injection. Diarrhea and porcine skin reactions; equine administration can be fatal. Marked overdose has caused shock and death in piglets. Species and route sensitivity remain important even when oral canine tolerance is relatively high.
Preparation Form Strength Route Tylosin injection 50 mg/mL Injection 50 mg / mL IM Tylosin injection 200 mg/mL Injection 200 mg / mL IM
Assess response and use appropriate injection site volume, not more than 10 mL/site. Colitis protocols can taper frequency after response.
Distinguish tartrate, phosphate and base strengths; reported guidance states tartrate is 80% tylosin base.
Product-specific treatment maxima are 5 days for cattle and 3 days for pigs; maximum injection-site volumes are 10 mL cattle and 5 mL pigs. Approximate powder teaspoon masses vary between 2.5-2.7 g and are not a verified density conversion. Historical slow IV cattle use conflicts with guidance to avoid IV administration; the route remains disputed.
