Table of Contents 28 sections Group Mechanism of Action Dose Rates Dogs Cats Cattle Sheep Goat Pigs Ferrets Chinchillas Gerbils Guinea pigs Hamsters Mice Rats Horses Chickens Turkeys Ducks Snakes Indications Contraindications Interactions Adverse effects Toxicity Preparations Monitoring and Administration
Neomycin Neomycin is an aminoglycoside antibacterial.
Aminoglycoside antibacterial
Binds bacterial 30S ribosomes; oral drug acts mainly within the intestinal lumen.
Dogs Use / stage Dose Route Schedule Instructions Enteric bacterial infection 10–20 mg/kg PO Every 6–12 h Up to 14 days Hepatic encephalopathy 20 mg/kg PO Every 8 h Do not use in: Intestinal bleeding or ulceration, Renal failure Portosystemic shunt adjunct 10–20 mg/kg PO Every 8–12 h Do not use in: Intestinal bleeding or ulceration, Renal failure Hepatic encephalopathy 20 mg/kg PO Every 12 h Do not use in: Intestinal bleeding or ulceration, Renal failure Hepatic encephalopathy 10–20 mg/kg PO Every 6 h Do not use in: Intestinal bleeding or ulceration, Renal failure Campylobacter enteritis 20 mg/kg PO Every 12 h Do not use in: Intestinal bleeding or ulceration, Renal failure Hepatic encephalopathy 15 mg/kg RECTAL Every 6 h After a cleansing enema; may be combined with lactulose.
Cats Use / stage Dose Route Schedule Instructions Enteric bacterial infection 10–20 mg/kg PO Every 6–12 h Up to 14 days Hepatic encephalopathy 22 mg/kg PO Every 8 h Do not use in: Intestinal bleeding or ulceration, Renal failure Hepatic encephalopathy 20 mg/kg PO Every 8–12 h Do not use in: Intestinal bleeding or ulceration, Renal failure Hepatic encephalopathy 20 mg/kg PO Every 12 h Do not use in: Intestinal bleeding or ulceration, Renal failure Campylobacter enteritis 20 mg/kg PO Every 12 h
Cattle Use / stage Dose Route Schedule Instructions Enteric bacterial infection 22 mg/kg PO Every 24 h Up to 14 days; Cattle regimen is for calves; daily oral amount. Susceptible enteric infection 7–12 mg/kg PO Every 12 h Enteric infection drinking-water regimen 11 mg/kg PO Mix the calculated amount into the drinking water consumed over 12 hours; water consumption determines delivery, not an IV or oral bolus schedule.
Sheep Use / stage Dose Route Schedule Instructions Enteric bacterial infection 22 mg/kg PO Every 24 h Up to 14 days; Cattle regimen is for calves; daily oral amount. Enteric infection drinking-water regimen 11 mg/kg PO Mix the calculated amount into the drinking water consumed over 12 hours; water consumption determines delivery, not an IV or oral bolus schedule.
Goat Use / stage Dose Route Schedule Instructions Enteric bacterial infection 22 mg/kg PO Every 24 h Up to 14 days; Cattle regimen is for calves; daily oral amount. Enteric infection drinking-water regimen 11 mg/kg PO Mix the calculated amount into the drinking water consumed over 12 hours; water consumption determines delivery, not an IV or oral bolus schedule.
Pigs Use / stage Dose Route Schedule Instructions Enteric bacterial infection 22 mg/kg PO Every 24 h Up to 14 days; Cattle regimen is for calves; daily oral amount. Susceptible enteric infection 7–12 mg/kg PO Every 12 h
Ferrets Use / stage Dose Route Schedule Instructions Susceptible enteric infection 10–20 mg/kg PO Every 6–12 h
Chinchillas Use / stage Dose Route Schedule Instructions Susceptible enteric infection 15 mg/kg PO Every 24 h
Gerbils Use / stage Dose Route Schedule Instructions Susceptible enteric infection 100 mg/kg PO Every 24 h
Guinea pigs Use / stage Dose Route Schedule Instructions Susceptible enteric infection 8 mg/kg PO Every 24 h
Hamsters Use / stage Dose Route Schedule Instructions Susceptible enteric infection 100 mg/kg PO Every 24 h
Mice Use / stage Dose Route Schedule Instructions Susceptible enteric infection 50 mg/kg PO Every 24 h
Rats Use / stage Dose Route Schedule Instructions Susceptible enteric infection 50 mg/kg PO Every 24 h
Horses Use / stage Dose Route Schedule Instructions Susceptible enteric infection 5–15 mg/kg PO Every 24 h
Chickens Use / stage Dose Route Schedule Instructions Enteric infection drinking-water regimen 11 mg/kg PO Mix the calculated amount into the drinking water consumed over 12 hours; water consumption determines delivery, not an IV or oral bolus schedule.
Turkeys Use / stage Dose Route Schedule Instructions Enteric infection drinking-water regimen 11 mg/kg PO Mix the calculated amount into the drinking water consumed over 12 hours; water consumption determines delivery, not an IV or oral bolus schedule.
Ducks Use / stage Dose Route Schedule Instructions Enteric infection drinking-water regimen 11 mg/kg PO Mix the calculated amount into the drinking water consumed over 12 hours; water consumption determines delivery, not an IV or oral bolus schedule.
Snakes Use / stage Dose Route Schedule Instructions Bacterial gastritis adjunct 15 mg/kg PO Oral neomycin is part of a gentamicin 2.5 mg/kg IM every 72 hours plus oral live-lactobacillus protocol; neomycin repeat interval unspecified.
Susceptible enteric bacterial infections Superficial bacterial infections Hepatic encephalopathy Portosystemic shunt adjunct Campylobacter enteritis Susceptible enteric infection Enteric infection drinking-water regimen Bacterial gastritis adjunct Renal disease and damaged intestinal mucosa increase risk of systemic toxicity. Do not inject oral products or continue oral treatment beyond 14 days. Mixing with other medicines may cause binding or inactivation. Oral neomycin can alter absorption of other drugs; systemic nephrotoxic or ototoxic agents can compound toxicity. Diarrhea and altered intestinal flora; absorbed drug can injure kidneys. Systemically absorbed neomycin can cause severe nephrotoxicity and ototoxicity. Damaged intestinal mucosa, renal disease and injectable exposure increase risk.
Preparation Form Strength Route Neomycin oral liquid (35 mg base/mL) Oral Liquid 35 mg / mL PO Neomycin oral liquid (140 mg base/mL) Oral Liquid 140 mg / mL PO
Monitor stool, hydration and renal indices when absorption or prolonged exposure is a concern. Benefit for nonspecific diarrhea is uncertain.
Prepare drinking-water or milk solutions freshly each day; avoid other liquid supplements.
Oral neomycin is contraindicated in rabbits and hares. Intestinal inflammation/bleeding increases absorption and renal/ear toxicity. Hepatic encephalopathy treatment also addresses lactulose, nutrition, electrolytes and GI bleeding; oral lactulose does not replace monitoring.
Historical parenteral systemic regimen is 3.5 mg/kg IV, IM or SC every 8 hours in dogs/cats, but is described as very nephrotoxic; no compatible sterile preparation or parent base/sulfate dose basis is established here. It is not assigned to oral products.
Older divided oral daily totals: adult cattle/horses 4-7.5 g/day, calves/foals 2-3 g/day, young pigs/lambs 0.75-1 g/day, in 2-4 divided doses. These general guides lack one defined per-administration interval. Equine intrauterine neomycin 3-4 g or multi-antibiotic mixtures are local procedures with poorly standardized diluents, volumes and intervals.
