Potentiates parasite glutamate-gated chloride channels, causing paralysis and death. Mammalian toxicity can occur when central nervous system exposure increases.
Schedule depends on the diagnosed parasite; no repeat interval is supplied for this general regimen.
Demodicosis
Reference only
PO
Begin at 100 mcg/kg/day and increase by 100 mcg/kg/day to 600 mcg/kg/day; typical courses 60-120 days, with duration determined by skin scrapings. This escalation must not be flattened into a freely selectable range.
Sarcoptic mange and cheyletiellosis
200–400 mcg/kg
PO
Every 168 h
Up to 42 days; Do not use in: ABCB1-associated macrocyclic-lactone sensitivity; Course 4-6 weeks.
Sarcoptic mange and cheyletiellosis
200–400 mcg/kg
SC
Every 336 h
Up to 42 days; Do not use in: ABCB1-associated macrocyclic-lactone sensitivity; Course 4-6 weeks.
Heartworm prevention
6–12 mcg/kg
PO
Every 720 h
Capillaria or Eucoleus lungworm
0.2 mg/kg
PO
Once
Oslerus osleri infection
0.4 mg/kg
SC
Once
Nasal-mite infection
0.2 mg/kg
SC
Once
Scabies
300–400 mcg/kg
PO, SC
Every 168 h
Do not use in: ABCB1-associated macrocyclic-lactone sensitivity
Cats
Use / stage
Dose
Route
Schedule
Instructions
Heartworm prevention
24 mcg/kg
PO
Every 720 h
Every 30 days.
Ectoparasite treatment
200–400 mcg/kg
IM, SC, PO
Every 168 h
Repeat only according to skin scrapings and clinical response; young kittens have increased toxicity risk.
Endoparasite treatment
200–400 mcg/kg
SC, PO
Every 168 h
Ear mites
Reference only
TOPICAL
Once
Per ear: 0.5 mL of 0.1 mg/mL feline ear product (50 mcg). Local ear administration must not convert through livestock pour-on or injectable preparations.
Aelurostrongylus abstrusus infection
0.4 mg/kg
SC
Once
Horses
Use / stage
Dose
Route
Schedule
Instructions
Nematode and bot control
200 mcg/kg
PO, IM
Once
Use the corresponding formulation as part of a parasite-control programme; oral solution example is 1 mL/50 kg at 10 mg/mL.
Lice or mange
0.2 mg/kg
PO
Every 96 h
Cattle
Use / stage
Dose
Route
Schedule
Instructions
Slow-release parasite control
Reference only
PO
Calves: 5.7-13.8 mg/kg as a single slow-release bolus, designed for 135 days. This is not an immediate-release dose.
Nematode and ectoparasite control
200 mcg/kg
SC
Once
Nematode and ectoparasite control
0.5 mg/kg
TOPICAL
Once
Pour-on formulation, 5 mg/mL; 1 mL/10 kg.
Goats
Use / stage
Dose
Route
Schedule
Instructions
Nematode and ectoparasite control
200 mcg/kg
SC
Once
Nematode and ectoparasite control
0.5 mg/kg
TOPICAL
Once
Pour-on formulation, 5 mg/mL; 1 mL/10 kg.
Meningeal-worm combination
Reference only
SC
Ivermectin 0.3 mg/kg daily plus fenbendazole 50 mg/kg PO daily for 5 days to limit further Parelaphostrongylus migration. Camelids may need gastric-ulcer protection; this is not single-drug treatment.
Sheep
Use / stage
Dose
Route
Schedule
Instructions
Nematode and ectoparasite control
200 mcg/kg
SC
Once
Nematode control
200 mcg/kg
PO
Once
Meningeal-worm combination
Reference only
SC
Ivermectin 0.3 mg/kg daily plus fenbendazole 50 mg/kg PO daily for 5 days to limit further Parelaphostrongylus migration. Camelids may need gastric-ulcer protection; this is not single-drug treatment.
Pigs
Use / stage
Dose
Route
Schedule
Instructions
Nematode and ectoparasite control
300 mcg/kg
SC
Once
Inject in the neck.
Potbellied-pig ectoparasites
300 mcg/kg
SC, IM
Every 240–336 h
One dose for endoparasites; a repeat 10-14 days later for ectoparasites. The IM alternative conflicts with cattle/swine product SC-only instructions; use formulation-specific assessment.
Ferrets
Use / stage
Dose
Route
Schedule
Instructions
Heartworm prevention
0.02 mg/kg
PO
Every 720 h
Historical slow heartworm-treatment protocol
Reference only
PO
50 mcg/ferret monthly is described as a very slow treatment approach, not a proven replacement for an individualized heartworm plan.
Rabbits
Use / stage
Dose
Route
Schedule
Instructions
Sarcoptoid mites
0.3–0.4 mg/kg
SC
Every 336 h
Two treatments 14 days apart; clean and disinfect housing.
Ear mites
0.2–0.44 mg/kg
PO, SC
Every 192–432 h
Repeat once after 8-18 days; 0.2 mg/kg SC with a 14-day repeat is another specific alternative.
Mice
Use / stage
Dose
Route
Schedule
Instructions
Mites
200 mcg/kg
SC, PO
Every 168 h
Up to 21 days; Treat colony contacts and disinfect housing.
Rats
Use / stage
Dose
Route
Schedule
Instructions
Mites
200 mcg/kg
SC, PO
Every 168 h
Up to 21 days; Treat colony contacts and disinfect housing.
Gerbils
Use / stage
Dose
Route
Schedule
Instructions
Mites
200 mcg/kg
SC, PO
Every 168 h
Up to 21 days; Treat colony contacts and disinfect housing.
Guinea pigs
Use / stage
Dose
Route
Schedule
Instructions
Mites
200 mcg/kg
SC, PO
Every 168 h
Up to 21 days; Treat colony contacts and disinfect housing.
Trixacarus caviae
500 mcg/kg
SC
Every 336 h
Up to 28 days; Three treatments on days 0, 14 and 28.
Chinchillas
Use / stage
Dose
Route
Schedule
Instructions
Mites
200 mcg/kg
SC, PO
Every 168 h
Up to 21 days; Treat colony contacts and disinfect housing.
Hamsters
Use / stage
Dose
Route
Schedule
Instructions
Mites
200–500 mcg/kg
SC, PO
Every 336 h
Up to 21 days
Llamas
Use / stage
Dose
Route
Schedule
Instructions
Gastrointestinal helminths
0.2 mg/kg
PO, SC
Once
Meningeal-worm combination
Reference only
SC
Ivermectin 0.3 mg/kg daily plus fenbendazole 50 mg/kg PO daily for 5 days to limit further Parelaphostrongylus migration. Camelids may need gastric-ulcer protection; this is not single-drug treatment.
Alpacas
Use / stage
Dose
Route
Schedule
Instructions
Gastrointestinal helminths
0.2 mg/kg
PO, SC
Once
Meningeal-worm combination
Reference only
SC
Ivermectin 0.3 mg/kg daily plus fenbendazole 50 mg/kg PO daily for 5 days to limit further Parelaphostrongylus migration. Camelids may need gastric-ulcer protection; this is not single-drug treatment.
Birds
Use / stage
Dose
Route
Schedule
Instructions
Nematodes or mites
200 mcg/kg
IM, PO
Every 240–336 h
Repeat once after 10-14 days; prepare a verified dilution immediately before dosing. Species-specific tolerance is required.
Nematodes or mites
220 mcg/kg
IM
General avian alternative; dilution concentration must be verified.
Nematodes or mites
200 mcg/kg
SC
Ratite nematodes
200 mcg/kg
PO, IM, SC
Reptiles
Use / stage
Dose
Route
Schedule
Instructions
Nematodes or ectoparasites
0.2 mg/kg
PO, IM, SC
Every 336 h
Do not use in: Chelonians, Indigo snakes, Skinks; Lizards, snakes and alligators: initial dose and one repeat in 2 weeks; a third only if still positive.
Stop exposure and provide respiratory and neurologic support. Prevent further absorption when appropriate; lipid-emulsion treatment may be considered in severe lipophilic-drug intoxication.
Establish heartworm status before preventive treatment and use fecal examinations or skin scrapings to assess other parasite responses.
Protect from light. Do not substitute concentrated livestock products for small-animal products without exact concentration and formulation assessment.
Kittens can be highly sensitive; neurotoxicity and death have occurred at 0.3-0.4 mg/kg in reported young cats.
For high-dose canine treatment, reported escalation approaches begin at 50-100 mcg/kg and increase by 50-100 mcg/kg/day while observing for neurotoxicity. Continue demodicosis treatment until 4 weeks after the second consecutive negative monthly skin scraping.
A preventative heartworm dose may precede adulticide treatment for 2-3 months. The described combined programme adds doxycycline 10 mg/kg PO daily for 28 days; it is not a substitute for a complete adulticide plan.
Published withdrawal figures in the reported guidance are formulation- and jurisdiction-specific; the goat injection meat figure of 35 hours is inconsistent with surrounding guidance and must not be used as a withdrawal instruction.
Alternative canine Demodex escalation increases 100 mcg/kg every third day until 600 mcg/kg/day, then treats 1-2 months beyond two negative scrapings. Another starts 50 mcg/kg, then 120 mcg/kg for a week, 200 mcg/kg for 3 days and increments 100 mcg/kg weekly. Keep these schedules separate; stop immediately for neurotoxicity. A doxycycline/ivermectin-pyrantel slow-kill study used doxycycline 10 mg/kg/day for 30 days and ivermectin 6-14 mcg/kg every 15 days for 6 months; clearance was incomplete and this is not a general adulticide recommendation.
For cattle SC injection, divide volumes greater than 10 mL between sites. The printed 200 mg/kg cattle IM instruction conflicts by 1000-fold with the repeated 200 mcg/kg dose and must not be used. Fixed Amazon/macaw doses lack sufficiently specific patient weights, and a finch amount lacks a route; no universal fixed-bird regimen is derived.
