Enrofloxacin is a veterinary fluoroquinolone antibacterial used for susceptible infections in a wide range of species. Its clinical spectrum emphasizes gram-negative bacilli, with activity against selected staphylococci and other organisms. It is used for companion-animal infections and species-specific livestock indications. Partial conversion to active ciprofloxacin contributes variably to antibacterial exposure.
Enrofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, disrupting DNA supercoiling, replication and separation of daughter chromosomes. Stabilization of enzyme–DNA cleavage complexes causes DNA damage and bacterial death. Activity is concentration dependent, with a post-antibiotic effect against susceptible organisms. The active metabolite ciprofloxacin contributes to the overall antibacterial effect to a species-dependent degree.
The source states 18–20 mg/kg once daily “every 3 days,” which is internally ambiguous between a 3-day course and a 72-hour interval. Not encoded numerically until resolved.
Cat
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
5 mg/kg
PO, IM
Every 24 h
Maximum total daily amount is 5 mg/kg; do not add a second route or additional daily dose.
Historical hemoplasmosis range
Reference only
PO
The additional text gives 5–10 mg/kg daily for 14 days, conflicting with the supplied feline maximum of 5 mg/kg/day and retinal-toxicity precautions. The higher range is not enabled.
Bird
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
15 mg/kg
PO, IM
Every 12 h
Poultry infection (Enrocare)
10 mg/kg
PO
Up to 5 days; Product describes drinking-water medication for 3–5 days. Daily water intake and dosing frequency require the actual flock prescription.
Empirical combination treatment
Reference only
PO
Stable immunocompetent psittacines: enrofloxacin 20 mg/kg daily with amoxicillin/clavulanate 125 mg/kg three times daily. Select therapy by culture when possible; combination is not automatically calculated.
Susceptible bacterial infection
15–20 mg/kg
SC
Every 24 h
Debilitated immunocompetent psittacines; inject into a fluid pocket.
Susceptible bacterial infection
15–20 mg/kg
SC
Every 12 h
Debilitated immunocompromised psittacines; inject into a fluid pocket.
Reptile
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
Reference only
PO, IM
The source gives 5 mg/kg/day but also every second or third day; choose a species-specific schedule before calculation.
Horse
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
5 mg/kg
IV, IM
Every 24 h
IM use requires rotating sites; IV administration must be slow.
Bacterial infection
7.5 mg/kg
PO
Every 24 h
Cattle
Use / stage
Dose
Route
Schedule
Instructions
Bovine respiratory disease
7.5–12.5 mg/kg
SC
Once
Bovine respiratory disease
2.5–5 mg/kg
SC
Every 24 h
Up to 5 days; Alternative daily course for 3–5 days.
Susceptible infection (Enroxsel-10)
2.5–5 mg/kg
SC
Up to 5 days; Product describes a 3–5-day course but does not explicitly state the repeat interval. Do not infer frequency from the concentration.
Pig
Use / stage
Dose
Route
Schedule
Instructions
Swine respiratory disease
7.5 mg/kg
IM, SC
Once
Behind the ear; no more than 5 mL at one injection site.
Buffalo
Use / stage
Dose
Route
Schedule
Instructions
Susceptible infection (Enroxsel-10)
2.5–5 mg/kg
SC
Up to 5 days; Product describes a 3–5-day course but does not explicitly state the repeat interval. Do not infer frequency from the concentration.
Sheep
Use / stage
Dose
Route
Schedule
Instructions
Susceptible infection (Enroxsel-10)
2.5–5 mg/kg
SC
Up to 5 days; Product describes a 3–5-day course but does not explicitly state the repeat interval. Do not infer frequency from the concentration.
Goat
Use / stage
Dose
Route
Schedule
Instructions
Susceptible infection (Enroxsel-10)
2.5–5 mg/kg
SC
Up to 5 days; Product describes a 3–5-day course but does not explicitly state the repeat interval. Do not infer frequency from the concentration.
Ferret
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
10–20 mg/kg
PO, IM, SC
Every 12 h
Rabbit
Use / stage
Dose
Route
Schedule
Instructions
Pasteurella respiratory infection
15–20 mg/kg
PO
Every 12 h
At least 14 days in mild disease; chronic infection may need a longer course.
Pasteurella respiratory infection — Initial
15–20 mg/kg
SC
Initial dose only; repeated SC dosing in this protocol risks severe tissue reactions.
Hedgehog
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, SC
Every 12 h
Chinchilla
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, IM
Every 12 h
Do not use in: Young growing animals
Susceptible bacterial infection
5–20 mg/kg
PO, SC
Every 24 h
Do not use in: Young growing animals
Gerbil
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, IM
Every 12 h
Do not use in: Young growing animals
Susceptible bacterial infection
5–20 mg/kg
PO, SC
Every 24 h
Do not use in: Young growing animals
Guinea Pig
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, IM
Every 12 h
Do not use in: Young growing animals
Susceptible bacterial infection
5–20 mg/kg
PO, SC
Every 24 h
Do not use in: Young growing animals
Hamster
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, IM
Every 12 h
Do not use in: Young growing animals
Susceptible bacterial infection
5–20 mg/kg
PO, SC
Every 24 h
Do not use in: Young growing animals
Mouse
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, IM
Every 12 h
Do not use in: Young growing animals
Susceptible bacterial infection
5–20 mg/kg
PO, SC
Every 24 h
Do not use in: Young growing animals
Rat
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
5–10 mg/kg
PO, IM
Every 12 h
Do not use in: Young growing animals
Susceptible bacterial infection
5–20 mg/kg
PO, SC
Every 24 h
Do not use in: Young growing animals
Chronic respiratory disease
10–25 mg/kg
PO
Every 12 h
Concurrent theophylline dose may require a 30% reduction.
Base selection on culture and susceptibility; activity against anaerobes and streptococci is poor.
Give equine IV doses slowly with compatible dilution; concentrated alkaline oral solutions may injure mucosa.
Monitor feline vision, neurologic signs and injection sites. Food-animal approvals and withdrawal rules are formulation- and jurisdiction-specific; foreign label intervals are not universal.
