At least 14 days; studies describe 3–4-week courses.
Heartworm adjunct
10 mg/kg
PO
Every 12 h
Up to 28 days; Wolbachia-directed course before adulticide treatment, within the complete heartworm protocol.
Toxoplasmosis
5–10 mg/kg
PO
Every 12 h
Up to 28 days
Granulocytic anaplasmosis
5 mg/kg
PO
Every 12 h
Up to 14 days
Salmon poisoning disease
10 mg/kg
IV
Every 12 h
At least seven days; Neorickettsia helminthoeca.
Antiarthritic adjunct
3–4 mg/kg
PO
Every 24 h
Up to 10 days; Reported course 7–10 days.
Cat
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
5 mg/kg
PO, IV
Every 12 h
Bacterial infection
10 mg/kg
PO
Every 24 h
Hemoplasmosis
10 mg/kg
PO
Every 24 h
Up to 7 days
Chlamydial or mycoplasmal infection
10–15 mg/kg
PO
Every 24 h
Chlamydial or mycoplasmal infection
5 mg/kg
PO
Every 12 h
Systemic bacterial infection
5–11 mg/kg
PO, IV
Every 12 h
Ehrlichiosis or anaplasmosis
5–10 mg/kg
PO
Every 12 h
Up to 21 days
Toxoplasmosis
5–10 mg/kg
PO
Every 12 h
Up to 28 days
Bird
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
25 mg/kg
PO
Every 12 h
Up to 21 days
Drinking-water medication
Reference only
PO
400 mg doxycycline hyclate per liter as the sole drinking water source; actual intake varies, so this is not a direct mg/kg calculation.
Chlamydiosis
35 mg/kg
PO
Every 24 h
Up to 21 days; Experimentally infected cockatiels; oral suspension delivered into the crop. This study course is not interchangeable with other avian protocols.
Chlamydiosis
40–50 mg/kg
PO
Every 24 h
Cockatiels, Senegal parrots, blue-fronted and orange-winged Amazons; conventional treatment course is 45 days.
Chlamydiosis
25 mg/kg
PO
Every 24 h
African grey parrots, Goffin cockatoos, blue-and-gold and green-winged macaws; conventional treatment course is 45 days.
Injectable chlamydiosis course
Reference only
IM
75–100 mg/kg every 5–7 days for four weeks, then every five days through a 45-day course. Alternative weekly regimens use 100 mg/kg, or 75 mg/kg in macaws and lovebirds, with the specified avian injectable product. Injectable preparations are not automatically interchangeable.
Horse
Use / stage
Dose
Route
Schedule
Instructions
Bacterial infection
20 mg/kg
PO
Every 12 h
Do not use in: IV administration
Lawsonia intracellularis infection
20 mg/kg
PO
Every 24 h
Up to 21 days
Granulocytic anaplasmosis
10 mg/kg
PO
Every 12 h
Up to 14 days; Alternative to oxytetracycline; reported course 10–14 days. Do not use IV doxycycline in horses.
Chinchilla
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2.5–5 mg/kg
PO
Every 12 h
Do not use in: Young growing animals, Pregnancy
Gerbil
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2.5–5 mg/kg
PO
Every 12 h
Do not use in: Young growing animals, Pregnancy
Guinea Pig
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2.5–5 mg/kg
PO
Every 12 h
Do not use in: Young growing animals, Pregnancy
Hamster
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2.5–5 mg/kg
PO
Every 12 h
Do not use in: Young growing animals, Pregnancy
Mouse
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2.5–5 mg/kg
PO
Every 12 h
Do not use in: Young growing animals, Pregnancy
Mycoplasmal pneumonia
Reference only
PO
Doxycycline 5 mg/kg every 12 hours with enrofloxacin 10 mg/kg every 12 hours.
Rat
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2.5–5 mg/kg
PO
Every 12 h
Do not use in: Young growing animals, Pregnancy
Mycoplasmal pneumonia
Reference only
PO
Doxycycline 5 mg/kg every 12 hours with enrofloxacin 10 mg/kg every 12 hours.
Ratite
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
2–3.5 mg/kg
PO
Every 12 h
Reptile
Use / stage
Dose
Route
Schedule
Instructions
Susceptible bacterial infection
10 mg/kg
PO
Every 24 h
Up to 45 days; Described courses range from 10–45 days; tortoise suspected mycoplasmal respiratory infection uses four weeks.
Always follow feline solid oral doses with water or food. Hyclate is particularly irritating if retained in the esophagus.
For IV use in suitable species, reconstitute then further dilute, commonly to 1 mg/mL, and infuse over 1–2 hours.
Monitor response and use susceptibility testing for ordinary bacterial infections; Enterobacterales and Pseudomonas are often resistant.
Aqueous compounded suspension stability is formulation dependent and can be short; a particular Ora-Plus/Ora-Sweet mixture retained potency for only 7 days. Darkening can indicate degradation.
