Table of Contents

Enalapril Maleate

Enalapril for animals is an ACE (Angiotensin Converting Enzyme) inhibitor. inhibits the conversion of angiotensin I to angiotensin II.

Group

Enalapril Maleate is grouped into ACE Inhibitors and Vasodilators.

Enalapril inhibits the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and also stimulates sympathetic stimulation, renal hypertension, and the synthesis of aldosterone. The ability of aldosterone to cause sodium and water retention contributes to congestion.

Enalapril causes vasodilation and decreases aldosterone levels.

Dose Rates

Dog and Cats: 0.5 to 1 mg/kg body weight q12-24hrs PO

Indications

To treat Hypertension
To treat Congestive Heart Failure (CHF)

Pimobendan, Frusemide (with Spironolactone or alone), and Digoxin are used with Enalapril in the management of Congestive Heart Failure.

Contraindications

Enalapril Maleate should not be given in Pregnant Animals

Interactions

If used with multiple hypotension-causing drugs, it may cause severe hypotension.

Adverse effects

Azotemia (In some patient)

Toxicity

An excessive dose of Enalapril can cause severe hypotension, which leads to the collapse of animals.

Management of hypotension in cases of toxicity should be done accordingly–

Fluid therapy
Adrenaline
Naloxone– an opioid receptor antagonist, has been shown to increase blood pressure in ACE inhibitor overdoses (read here)
Activated Charcoal in case of oral ingestion

Preparations

Only oral preparations are used in animals.

Oral Preparations of Enalapril Maleate available-

Tab. Envas 2.5 (Enalapril Maleate 2.5mg)
Tab. Envas 5 (Enalapril Maleate 5mg)
Tab. Envas 10 (Enalapril Maleate 10mg)
Tab. Dilvas-2.5 (Enalapril Maleate 5mg)
Tab. Dilvas-5 (Enalapril Maleate 5mg)
Tab. Dilvas-10 (Enalapril Maleate 10mg)
Tab. Enatol-5 (Enalapril Maleate 5mg)
Tab. Enatol-10 (Enalapril Maleate 10mg)
Tab. Enapril-5 (Enalapril Maleate 5mg)
Tab. Enapril-10 (Enalapril Maleate 10mg)
Tab. Enace-2.5 (Enalapril Maleate 2.5mg)
Tab. Enace-5 (Enalapril Maleate 5mg)
Tab. Enace-10 (Enalapril Maleate 10mg)
Tab. Lepril-2.5 (Enalapril Maleate 2.5mg)
Tab. Lepril-5 (Enalapril Maleate 5mg)
Tab. Lepril-10 (Enalapril Maleate 10mg)

More about Enalapril for animals

Enalapril Maleate (Envas 5mg, Envas 10mg, Dilvas 5mg and Dilvas 10mg) for Animals (especially for cat and Dogs)

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Enalapril for Animals